Fig. 5

Visualization of ADAR expression and ADAR editing landscapes. a ADAR expression is significantly increased in CZS phenotype cell lines K048 (ANOVA F-statistic (F) = 58.396, significance p-value (p) = 0.001575) and K054 (F = 18.516, p = 0.01261), but not in phenotypically normal G010 (F = 0.1219, p = 0.7446) cells. b ADAR1p150 expression is significantly higher in K048 (F = 29.497, p = 0.005576), but not in K054 (F = 2e−04, p = 0.9902) or G010 (F = 3.4772, p = 0.1357) cells. c ADARB1 expression is not significantly different in K048 (F = 0.2579, p = 0.6383) or K054 (F = 1.0492, p = 0.3636) cells, but is significantly higher in G010 (F = 14.684, p = 0.01859). d The numbers of A to G substitutions were somewhat elevated in K048 (F = 6.0422, p = 0.06984), but not in G010 (F = 6e−04, p = 0.9813) or K054 cells (F = 0.0648, p = 0.8116). e The numbers of A to G substitutions with predicted high impact on protein structure and function were significantly lower in G010 (F = 17.498, p = 0.01388), but somewhat higher in K048 cells (F = 6.3489, p = 0.06538); there were no changes in K054 cells (F = 1.7384, p = 0.2578). Likewise, moderate impact substitutions were also significantly lower in G010 (F = 15.737, p = 0.01658) and significantly higher in K048 (F = 157.23, p = 0.0002328) cells, while were not changed in K054 cells (F = 1.9198, p = 0.2381) (f)