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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Molecular dynamics of the immune checkpoint programmed cell death protein I, PD-1: conformational changes of the BC-loop upon binding of the ligand PD-L1 and the monoclonal antibody nivolumab

Fig. 3

Binding of PD-L1 and Nivolumab to PD-1. a Central member structure of cluster 3 of the BC-loop, binding to PD-L1; PD1- in grey, with the BC-loop in red sticks and PD-L1 in orange. b Central member structure of cluster 1 of the BC-loop, binding to Nivolumab; PD-1 in grey, with the BC-loop in blue sticks and Nivolumab in light blue. Hydrogen bonds between PD-1 and Nivolumab observed in this structure indicated in green. c, d zoomed in views of (a, b), respectively. PD-1 is in the same orientation in all four panels

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BMC Bioinformatics

ISSN: 1471-2105

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