Table 7 The novel drug-disease interactions of the top five drugs predicted by SNF-NN along with their source of evidence, where a hyphen indicates a previously unknown drug-disease interaction

Dexamethasone

Endometriosis

ClinicalTrials.gov

Hereditary Orotic Aciduria

PubMed

Hepatitis C, Chronic

PubMed

Mineral Deficiency

DrugBank.ca

Urinary Tract Infection

ClinicalTrials.gov

Q Fever Endocarditis

PubMed

Hepatolenticular Degeneration

–

Levofloxacin

Vomiting

PubMed

Mixed Anxiety and Depressive Disorder

PubMed

Lymphogranuloma Venereum

PubMed

Echinococcus Granulosus Infection of Liver

PubMed

Schistosomiasis

PubMed

Malignant Neoplasm of Stomach Stage IV

–

Scurfiness of Scalp

–

Loteprednol

Streptococcal Pneumonia

PubMed

Dry Eye Syndromes

ClinicalTrials.gov

Tinea Cruris

–

Sepsis Due to Staphylococcus Aureus

–

Drug-Induced Mucositis

–

Yaws

–

Relapsing Fever

–

Sparfloxacin

Pneumonia due to Klebsiella Pneumoniae

DrugBank.ca

Urinary Retention

PubMed

Intractable Hiccups

–

Salmonella Sepsis

–

Osteoporosis, Postmenopausal

–

Dacryocystitis

–

Uric Acid Renal Calculus

–

Triamcinolone

Impetigo

PubMed

Osteoporosis

PubMed

Coughing

ClinicalTrials.gov

Obesity

ClinicalTrials.gov

Multiple Myeloma

PubMed

Gonococcal Joint Infection

–