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Table 7 The novel drug-disease interactions of the top five drugs predicted by SNF-NN along with their source of evidence, where a hyphen indicates a previously unknown drug-disease interaction

From: SNF-NN: computational method to predict drug-disease interactions using similarity network fusion and neural networks

Drug name Disease name Evidence
Dexamethasone Endometriosis ClinicalTrials.gov
  Hereditary Orotic Aciduria PubMed
  Hepatitis C, Chronic PubMed
  Mineral Deficiency DrugBank.ca
  Urinary Tract Infection ClinicalTrials.gov
  Q Fever Endocarditis PubMed
  Hepatolenticular Degeneration
Levofloxacin Vomiting PubMed
  Mixed Anxiety and Depressive Disorder PubMed
  Lymphogranuloma Venereum PubMed
  Echinococcus Granulosus Infection of Liver PubMed
  Schistosomiasis PubMed
  Malignant Neoplasm of Stomach Stage IV
  Scurfiness of Scalp
Loteprednol Streptococcal Pneumonia PubMed
  Dry Eye Syndromes ClinicalTrials.gov
  Tinea Cruris
  Sepsis Due to Staphylococcus Aureus
  Drug-Induced Mucositis
  Yaws
  Relapsing Fever
Sparfloxacin Pneumonia due to Klebsiella Pneumoniae DrugBank.ca
  Urinary Retention PubMed
  Intractable Hiccups
  Salmonella Sepsis
  Osteoporosis, Postmenopausal
  Dacryocystitis
  Uric Acid Renal Calculus
Triamcinolone Impetigo PubMed
  Osteoporosis PubMed
  Coughing ClinicalTrials.gov
  Obesity ClinicalTrials.gov
  Multiple Myeloma PubMed
  Gonococcal Joint Infection