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Table 4 The sensitivity and the specificity of the five methods at an alpha cutoff of 0.05

From: A comparison of curated gene sets versus transcriptomics-derived gene signatures for detecting pathway activation in immune cells

Signature Generation Data-derived signature Curated gene set
Method Sensitivity Specificity Sensitivity Specificity
Mann-Whitney-Wilcoxon Enrichment 0.7655 0.3098 0.25 0.7292
Fisher’s Exact Concordance 0.7977 0.3720
Fisher’s Exact Overrepresentation 0.8981 0.1014 0.5246 0.6229
Correlation Permutation 0.7278 0.4517
Concordance Permutation 0.7424 0.3995