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Fig. 4 | BMC Bioinformatics

Fig. 4

From: Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt

Fig. 4

Number of cells in the crypt as a function of mutation parameter. Top) Averaged over 100 simulations for constant (η=1) and variable drag (Equation (3)). All cells are mutated in a dynamic equilibrium, at time t=0, the number of cells are counted at t=50 hours. Dashed lines are with the VL model and solid line are with the Tan model. Bottom) Snapshots of simulations using the adhesion complex dependent drag functions defined in Equation (3). (random seed = 0). Proliferative cells are outlined in blue and cell color indicates level of nuclear complex. All cells in the crypts are mutated at time t=0h, with parameter γ=0.5, for both models

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