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Fig. 6 | BMC Bioinformatics

Fig. 6

From: Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt

Fig. 6

Mutant cells invade the crypt. Top) probability of mutant cells taking over the crypt as a function of initial proportion of mutated cells, for the VL and Tan models as the mutation parameter γ is varied. results are presented for γ=0 (red),0.5,0.75,0.9, and 1 (blue) and the arrow is in the direction of increasing γ Bottom) Snapshots of 2 simulations with 50% mutated cells. In the top simulation healthy cells happen to out compete the mutant cells, in the bottom simulation mutant cells win. Note, specific simulations were chosen to illustrate the conversion to homogeneous crypts

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