Fig. 3

MEK bound RAF. Independently from the frequencies of the tested perturbations, the variation of T_{RAFact + MEKd → MEKact} leaves the MAPK sub module of the network unchanged exception for the MEK interacting with RAF which is highly sensitive to the parameter. Indeed, the distribution of recurrence of events for active MEK bounded to RAF is bimodal in τ = {4, 9} s. For small value of T_{RAFact + MEKd → MEKact} ∼ 10 s the distribution is mainly centred around τ = 4 s and it represents the main mode, while for larger value of T_{RAFact + MEKd → MEKact} the distribution’s main mode is at τ = 9 s. (a) T = 1000 s; (b) T = 200,000 s; (c) T_{RAFact + MEKd → MEKact} = 10 s; and (d) T_{RAFact + MEKd → MEKact} = 1320 s