Fig. 4

MEK + ERK, ERK and RUNX2. Distributions for different values T_{ERKact → ERKd} under a periodic perturbation with P = 1000 s and M = 10,000 μPa. T_{ERKact → ERKd} produces larger effects on the next nearest neighbour of the network like unphosphorylated RUNX2 and unphosphorylated ERK. Variations in the distributions and in the non-normalized histogram of MEK bounded to ERK. No effects are visible on the distribution of active ERK dissociated from MEK. Amplitudes or number of fluctuations of ERK dissociated MEK increase with the increase of T_{ERKact → ERKd}, while they show an inverse relation for MEK bound to ERK decrease