Fig. 5

MEK-ERK, ERK and RUNX2. Distributions for different values of T_{ERKact → ERKd} under a periodic perturbation with P = 200,000 s and M = 10,000 P a. The distributions are similar to those obtained with higher frequency stimulation. The histograms show larger or more frequent fluctuations of unphosphorylated RUNX2 and MEK bound ERK