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Table 3 Distribution of 139 alanine scanned interface residues among the seven amino acid classes

From: Analyses on clustering of the conserved residues at protein-RNA interfaces and its application in binding site identification

Amino acid classNum in entire datasetNum of hot spot residues (ΔΔG ≥ 2.0 kcal/mol)percentage of hot spot residues
Ala, Val, Leu, Ile, Met, Cys3133.33%
Gly, Ser, Thr19315.79%
Asp, Glu1616.25%
Asn, Gln1815.56%
Arg, Lys491020.41%
Pro, Phe, Tyr, Trp271659.26%