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Fig. 2 | BMC Bioinformatics

Fig. 2

From: OffsampleAI: artificial intelligence approach to recognize off-sample mass spectrometry images

Fig. 2

Representative off-sample ion images from the gold standard datasets illustrating a variety of spatial patterns exhibited by such images as well as particular aspects of the imaging MS datasets. a-c: Illustrative images from several datasets showing the indicative off-sample pattern (high intensities outside of the tissue section) from DESI- (a) and MALDI-imaging (b-c). d: A dataset with several tissue sections. e: A non-rectangular dataset where the acquisition area was selected around a whole body mouse tissue section. f: The indicative off-sample pattern. g: A gradually-changing off-sample pattern. h-k: Different spatial patterns of off-sample images in the same dataset (MALDI-imaging, DHB matrix). h: The indicative pattern. i: Everywhere-pattern. j: Gradually-changing pattern. k: Spotty pattern with spots everywhere, potentially due to a special matrix (DHB) application. l-o: Different spatial patterns of off-sample images in the same dataset (DESI-imaging). l: Mainly off-sample localization. m: Gradual off-sample localization. n: Off-sample leakage pattern. o: Everywhere pattern. p-s: Examples of off-sample MALDI ion images with only a narrow band of off-sample pixels due to the acquisition area selected precisely around the tissue section. METASPACE links to the ion images: a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s. For acknowledgements for these and other gold standard datasets, see section Acknowledgements

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