Fig. 1
From: Modeling methylation dynamics with simultaneous changes in CpG islands
a We consider cells to have evolved like species in a lineage tree. Instead of DNA we consider at methylation data, where we categorize CpG sites as unmethylated, partially methylated and methylated. Sites are contained within CpG islands, which we assume to evolve independently. b The IWE-SSE model is two stage model that considers both events that concern individual sites (SSEs), as well as events that change the probability of methylation states (IWEs) in whole islands during evolution. c Location of IWEs and their corresponding probabilities are inferred by inserting proposed IWEs in a tree, and then accepting the proposal with a Metropolis Hastings acceptance probability