Fig. 2
From: Variant effect predictions capture some aspects of deep mutational scanning experiments
Recall proportional to deleterious DMS effect scores. The continuous normalized DMS scores with deleterious effect in SetCommon were split into 20 bins of equal size. a In each bin the fraction of SAVs predicted as having an effect by the binary classification methods (PolyPhen-2 [37], SIFT [39] and SNAP2 [38]) was shown. Naïve Conservation read off PSI-BLAST profiles was treated as an effect prediction when scores were above 0. For all other methods the default score thresholds were applied. b shows the values adjusted for the amount of effect predicted in the first bin