Fig. 4
From: Variant effect predictions capture some aspects of deep mutational scanning experiments
Classification performance of all prediction methods. Shown are ROC curves for 13,796 deleterious effect SAVs which were classified into either neutral, defined by the middle 95% of the scores from synonymous variants, or effect (SetCommonSyn95). Shaded areas around lines denote 95% confidence intervals. The legend denotes the AUC for each of the five prediction methods, along with the 95% confidence intervals. Horizontal dashed lines denote the default score threshold used by SNAP2 (blue) and SIFT (green)