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Fig. 4 | BMC Bioinformatics

Fig. 4

From: Variant effect predictions capture some aspects of deep mutational scanning experiments

Fig. 4

Classification performance of all prediction methods. Shown are ROC curves for 13,796 deleterious effect SAVs which were classified into either neutral, defined by the middle 95% of the scores from synonymous variants, or effect (SetCommonSyn95). Shaded areas around lines denote 95% confidence intervals. The legend denotes the AUC for each of the five prediction methods, along with the 95% confidence intervals. Horizontal dashed lines denote the default score threshold used by SNAP2 (blue) and SIFT (green)

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