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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Network hub-node prioritization of gene regulation with intra-network association

Fig. 3

The mTor pathway for the epithelial ovarian carcinoma study. a Network plot. Nodes in red are hubs with degree ā‰„3, nodes in yellow are of degree 2, and nodes in light blue are of degree ā‰¤1. b Scree plot (blue dots) of the relative influence of gene nodes (left Y-axis). The right Y-axis is the negative-logarithm-p-value (grey bar). The dashed red line corresponds to pā€‰=ā€‰0.05, and the solid red line to 0.05 divided by the number of nodes inside the pathway. The X-axis label indicates the gene node. A name followed by an * indicates more than one gene is contained inside this node. The number in parenthesis is the ranking determined by p-value. c Heatmap for comparing rankings under different methods. Gene nodes ranked among the first 25% are colored in grey. The nodes considered hubs are denoted in red. The number in parentheses after the gene symbol indicates the degree of the node. d Ranking list

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