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Table 3 Putative driver gene sets discovered by QuaDMutNetEx

From: QuaDMutNetEx: a method for detecting cancer driver genes with low mutation frequency

GenecD/RQuanDMutExCOSMICDDBv2GenecD/RQuanDMutExCOSMICDDBv2
TN: Triple-negative breast cancer           
TP5335RPARK26
ATR4DSAGE13
NR3C13CREBBP2D/R
DAPK12NCOA12D
SLC39A72IDH3B2
HIST1H4A2HIF1A2D
MLL2D      
GBM: Glioblastoma multiforme           
CDKN2A55RTP5338R
MDM213DMDM45D
MAPK92RPL112
HGS: high-grade serous ovarian cancer           
TP53249RSOS13
CTNNB12DDAG12
ERBB22DFANCA2R
GRB22PIK3R12R
TSHR2DDNAJA32
HSP90AA12DHSPA52
MST1R2PTK22
STAT32DUBC2
VAV32WRN2R
ZAP702ERBB32D
NTRK22SPRY22
DHHC112JAK22D
CDKN2A2R      
METABRIC: breast cancer           
ERBB284DFGFR150D
GAB235PSG1128
MACROD219PTEN16D
FRS210IGF1R10
CRK10JAK27D
AC116165.7-26IRS46
PTK25IL6ST4D
EGFR4DGRB24
PTPN14CREBBP3D/R
DOK63JAK12D
EGF2PIK3R12R
SYK2DPTPN62
VAV12      
  1. Number of patients in the dataset that had a mutation in the gene is in c column. D/R stand for dominant or recessive otherwise unknown. Genes discovered by the quadratic mutual-exclusivity approach that does not include the network connectivity term are in QuanDMutEx column. COSMIC [26, 27] column represent if the gene present in COSMIC Cancer Gene Census. Genes present in DriverDBv2 [28] are in DDBv2 column