Fig. 4

Performance evaluation of CN detection tools on the simulated datasets. a Coverage plot of simulated data containing spiked-in LCVs and FAs (top panel). Coverage plot of original CHP-212 Chr 12 (bottom panel) from which simulated data has been derived. b Bar graph showing false positive and true positive FAs detected by different tools. c Performance measurements (precision, recall and f-measure) of CNA detection tools for FAs. d Performance evaluation of FA calls by the ROC curves. e Line graph showing changes in CNAtra-estimated CN reference (dotted red line) and the global RD median (dotted black line) with each successive addition of artificial (simulated) chromosome in IMR-32 (square), CHP-212 (circle) and HepG2 (cross) datasets