Fig. 2
From: Self-analysis of repeat proteins reveals evolutionarily conserved patterns
Dot plot patterns are maintained over evolutionary time in repeat proteins. For all sets of images, the leftmost figure is the consensus figure made from a set of related proteins. Black pixels indicate a DOTTER score of ≥31. A) An arrow like structure is evident in the consensus (left) and homologs of the plant RAP protein (no structure currently but reported to contain OPR repeats) among the vascular plants from the flowering plant (S. tuberosum, center) and is also evident in the earlier diverged species such as the byrophyte mosses (P. patens, right, 41.7% group sequence similarity, JX = 0.072). B) The slow sequence changes in the regulator of chromosome condensation (RCC, RepeatsDB class 4.8, consensus left) protein with its 7-bladed propeller repeat structure maintains a fairly simple, regular pattern along with a more complex one closer to the C-terminus as demonstrated by proteins from the black cottonwood tree (P. trichocarpa, center) and the obligate marine actinomycete (S. arenicola, right) despite only 23.6% group sequence similarity (JX = 0.053). C) A very complex dot plot pattern is evident among the DSCA proteins (RepeatsDB class 5.5, consensus left) in animals with examples given from the mammalian (H. glaber, center) and avian lineages (C. anna, right) with overall group 57.5% sequence similarity, JX = 0.118). D) Similarity among the vertebrate CDC23 (RepeatsDB class 3.3, consensus left) proteins is also high and the protein maintains a complex dot plot demonstrated in both the fish (N. korthausae, center) and duck (A. platyrhynchos, right) homologs (83.1% group sequence similarity, JX = 0.217). Larger versions of these panels are given as SI Fig. 9