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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Adaptations of Escherichia coli strains to oxidative stress are reflected in properties of their structural proteomes

Fig. 2

Classifying strains by predicted endogenous ROS levels and missing reactions that contribute to the predicted phenotype. a Simulations of strain-specific metabolic models enable the prediction of endogenous ROS levels, or ROStype. A defined ROStype results from changes to pathway usage due to the deletion of certain reactions from missing genes. Strains are classified by their predicted endogenous ROS levels as “high” (ROShi) or “low” (ROSlo) ROStypes if their predicted rates of production of hydrogen peroxide (H2O2) or superoxide (O2) differ by more than 5% from the measured production rate in the K-12 MG1655 strain (orange dotted line). If predicted endogenous ROS levels do not differ by more than 5%, a strain is classified as similar to MG1655 (ROSK-12). b Histogram of the metabolic subsystems of missing reactions that contribute to the ROStype. Reactions that are shared between strains with ROShi and ROSlo predictions are denoted as shared missing reactions in gray

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