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Fig. 4 | BMC Bioinformatics

Fig. 4

From: Origins and characterization of variants shared between databases of somatic and germline human mutations

Fig. 4

Candidate correlates of shared variant rate across somatic tissues. The similarity of three different epigenetic marks (RNA transcription, chromatin accessibility via DNase I hypersensitivity, and replication timing) between somatic tissues and a germline-like stem cell do not correlate with the rates of variants that the somatic tissues share with the germline database. a, b, c Somatic tissues with a higher proportion of variants attributed to the “clock-like” endogenous mutational signature 1 have higher Forbes coefficients. d The associations of stem cell division rate with shared variant rates and if median mutation load and shared variant rates across somatic tissues does not reach significance (e, f). For TCGA project code abbreviations, see Table 3

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