Fig. 5

The shared variant rate of germline variants by allele age and ancestry. More recently-derived germline variants, including de novo variants, have higher rates of being somatically-shared. Points are labeled according to the number of variants within the age bin corresponding to each set of variants. a Ultra-rare germline variants present on multiple continents have higher rates of being somatically-shared. b Among germline variants unique to one continental ancestry in our data set, variants from donors of European ancestry have higher rates of being shared with the somatic database than do variants from any other continental ancestry. c Exclusively European germline variants have elevated rates of being shared with somatic samples of any continental ancestry, and no other germline continental ancestry has a markedly higher shared variant rate when comparing with somatic variants of each continental ancestry. (D) NFE = Non-Finnish European; AMR = Admixed American; EAS = East Asian; AFR = African or African American