Skip to main content

Table 2 Conditioned Forbes scores after partitioning the exome into successively finer nucleotide contexts

From: Origins and characterization of variants shared between databases of somatic and germline human mutations

Model classPartitions into which nucleotide contextNumber of partitionsNumber of expected shared variantsPartition-conditioned Forbes coefTotal shared SNVs explainedIncremental explanatory value
Statistical IndependenceUnpartitioned1115,8142.91034.4%34.4%
Basic mutation typeDeamination vs transition vs transversion3294,6191.14487.4%53.0%
Extended nucleotide contextTrinucleotide96301,7281.11789.5%2.1%
Pentanucleotide1536305,5111.10390.7%1.2%
Heptanucleotide24,576307,3931.09691.2%0.5%