Table 2 Conditioned Forbes scores after partitioning the exome into successively finer nucleotide contexts
Model class | Partitions into which nucleotide context | Number of partitions | Number of expected shared variants | Partition-conditioned Forbes coef | Total shared SNVs explained | Incremental explanatory value |
|---|---|---|---|---|---|---|
Statistical Independence | Unpartitioned | 1 | 115,814 | 2.910 | 34.4% | 34.4% |
Basic mutation type | Deamination vs transition vs transversion | 3 | 294,619 | 1.144 | 87.4% | 53.0% |
Extended nucleotide context | Trinucleotide | 96 | 301,728 | 1.117 | 89.5% | 2.1% |
Pentanucleotide | 1536 | 305,511 | 1.103 | 90.7% | 1.2% | |
Heptanucleotide | 24,576 | 307,393 | 1.096 | 91.2% | 0.5% |