Fig. 3

Computational pipeline for computing ceRNA interactions. The pipeline is based on the data extracted for different data sources (see Table 1). Using the hypethergeometric test (a) an initial set of putative ceRNA-A, miRNA, ceRNA-B triplets is found. Then we filtered only the couple miRNA-target having a negative correlation according to the globaltest (b). Finally we apply the SPONGE algorithm to the ceRNA interactions obtained in the previous steps (c). The resulting ceRNA interactions are computed for each cancer tissue