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Table 3 Top 25 pathways associated with specific mRNA targets of the isomiR AUGGCACUGGUAGAAUUCACUG_hsa-miR-183-5p_1_0_0_1_NA_0_NA_F_NA

From: IsomiR_Window: a system for analyzing small-RNA-seq data in an integrative and user-friendly manner

Pathway name

Entities

Reactions

Found

Ratio

p value

FDR*

Found

Ratio

Defective EXT1 causes exostoses 1, TRFS2 and CHDS

5/16

7.87e-04

0.026

0.996

4/4

3.25e-04

Defective EXT2 causes exostoses 2

5/16

7.87e-04

0.026

0.996

4/4

3.25e-04

Defective B3GALT6 causes EDSP2 and SEMDJL1

5/21

0.001

0.067

0.996

1/1

8.12e-05

Defective B3GALT7 causes EDS, progeroid type

5/21

0.001

0.067

0.996

1/1

8.12e-05

Defective B3GAT3 causes JDSSDHD

5/22

0.001

0.079

0.996

1/1

8.12e-05

Negative regulation of TCF-dependent signaling by DVL-interacting proteins

2/5

2.46e-04

0.094

0.996

2/2

1.62e-04

Keratan sulfate biosynthesis

8/39

0.002

0.11

0.996

8/9

7.31e-04

NOTCH2 Activation and Transmission of Signal to the Nucleus

6/32

0.002

0.115

0.996

11/11

8.94e-04

HS-GAG biosynthesis

7/40

0.002

0.121

0.996

13/14

0.001

Interleukin-21 signaling

3/12

5.90e-04

0.127

0.996

5/5

4.06e-04

Phase 3- rapid repolarisation

3/12

5.90-e04

0.127

0.996

2/2

1.62e-04

O-linked glycosylation of mucins

11/73

0.004

0.136

0.996

17/17

0.001

Acyl chain remodelling of PS

6/34

0.002

0.14

0.996

4/8

6.50e-04

WNT ligand secretion is abrogated by PORCN inhibitor LGK974

1/2

9.84e-05

0.185

0.996

1/1

8.12e-05

Defective PMM2 causes PMM2-CDG (CDG-1a)

1/2

9.84e-05

0.185

0.996

1/1

8.12e-05

Defective SLC26A4 causes Pendred syndrome (PDS)

1/2

9.84e-05

0.185

0.996

1/1

8.12e-05

Acyl chain remodelling of PI

5/30

0.001

0.198

0.996

3/6

4.87e-04

RNF mutatnts show enhanced WNT signaling and proliferation

2/8

3.93e-04

0.199

0.996

1/1

8.12e-05

Mitochondrial calcium ion transport

5/31

0.002

0.216

0.996

5/10

8.12e-04

Retinoid metabolismo and transport

17/107

0.005

0.216

0.996

10/28

0.002

IRAK1 recruits IKK complex

3/16

7.87e-04

0.227

0.996

4/4

3.25e-04

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

3/16

7.87e-04

0.227

0.996

4/4

3.25e-04

Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)

2/9

4.43e-04

0.236

0.996

3/3

2.44e-04

Erythropoietin activates STAT5

2/9

4.43e-04

0.236

0.996

3/3

2.44e-04

STAT5 activation

2/9

4.43e-04

0.236

0.996

3/3

2.44e-04