Skip to main content

Table 2 Summary of enrichment analysis on survival significant modules detected by different algorithms

From: TPSC: a module detection method based on topology potential and spectral clustering in weighted networks and its application in gene co-expression module discovery

  Biological processes Pathways Cytobands
TPSC-w Cell cycle and mitotic process (G1, G12) HTLV-I infection and Prostate cancer (G1) 3p21.3 and 8p12-p11 (G1)
   P53 signaling, PI3K-AKt signaling and FOXO signaling pathway (G12) 7q21.3, 1q32 and 17q22-q23 (G12)
    17q11.2(G1, G12)
TPSC-1 Extracellular matrix and structure organization, blood vessel development, cell adhesion and motility (M6) Extracellular matrix organization, collagen formation and ensemble of genes encoding ECM-associated proteins (M6) 11q22.3 and 13q34 (M6)
  Response to growth hormone (M16) Pathways related to RHO GTPases (M21, M23) 17q11.2 and 6q22-q23 (M16)
  Cell cycle and mitotic process (M21, M23) Proteoglycans in cancer and circadian clock (M21) 1p32 (M23)
   Antifolate resistance (M23)  
WGCNA Cell cycle and mitotic process (W2) P53 signaling, oocyte meiosis and PI3K-AKt infection (W2) 20q11.2 and 12q13.12 (W2)
  Activation of T cell, lymphocyte and leukocyte (W13) Cytokine, NF-Kappa B, chemokine and TNF signaling(W13) 1q31-q32, 1p36 and 1q23 (W13)
lmQCM Cell cycle and mitotic process(Q4) RHO GTPases pathways, P53 pathways, oocyte meiosis and HTLV-I infection (Q4) 12q13.12, 2p24.2, 15q15.1 and 4q27(Q4)
  Epithelial cell development and mammary gland development (Q7) ERBB2- and ERBB4-related signaling (Q7) 4q31.21 and 1p33(Q7)