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Table 3 Real data: Comparison of estimation of the number of non-redundant variates from the permutation method (ENT, obtained as the average of the ENT estimates for all the clinical outcomes measures considered via the multivariate Normal and the multivariate log-Normal methods) and via approximation procedures based on the eigenvalues of the correlation matrix of the metabolite concentrations (Meff)

From: Multiple-testing correction in metabolome-wide association studies

 

MESA BINNED

MESA NOESY

MESA CPMG

ENT

352(53.8%)

2744(9.0%)

16014(52.3%)

Meff.MWSL

345(52.7%)

1931(6.3%)

11570(37.8%)

Meff.Galwey [10]

201(30.7%)

524(1.7%)

1815(5.9%)

Meff.Gao [9]

435(66.4%)

2705(8.8%)

3537(11.6%)

Meff.Liji [8]

226(34.5%)

2534(8.3%)

4972(16.3%)

Meff.Nyholt [7]

611(93.3%)

26823(87.7%)

29704(97.1%)

  1. R = ENT/ANT(%) ratio in brackets. ANT = 655 for the MESA BINNED data, and ANT = 30590 for the NOESY and CPMG data. Meff estimates closest to ENT estimates in bold