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Table 7 BINNED data: ENT estimates with 95% confidence intervals in brackets, and type I error estimation from the permutation procedure for various simulated outcome measures: continuous, discrete-binary, discrete-count, time-to-event survival

From: Multiple-testing correction in metabolome-wide association studies

Outcome type Continuous Binary Count Survival
MESA Binned data ENT R (%) Type I error (%) ENT R (%) Type I error (%) ENT R (%) Type I error (%) ENT R (%) Type I error (%)
Identity 482 (442;506) 74 5.16 409 (379;443) 62 5.11 221 (198;256) 34 4.71 466 (431;505) 71 4.97
Multivariate log-normal 351 (316;388) 54 5.02 338 (310;380) 52 5.01 344 (305;377) 53 4.71 344 (309;366) 53 4.92
Multivariate normal 376 (345;423) 57 5.04 355 (318;395) 54 5.21 366 (326;404) 56 4.69 361 (331;397) 55 4.81
  1. \(K=5000\) permutations. ANT=655