Table 7 BINNED data: ENT estimates with 95% confidence intervals in brackets, and type I error estimation from the permutation procedure for various simulated outcome measures: continuous, discrete-binary, discrete-count, time-to-event survival
From: Multiple-testing correction in metabolome-wide association studies
Outcome type | Continuous | Binary | Count | Survival | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
MESA Binned data | ENT | R (%) | Type I error (%) | ENT | R (%) | Type I error (%) | ENT | R (%) | Type I error (%) | ENT | R (%) | Type I error (%) |
Identity | 482 (442;506) | 74 | 5.16 | 409 (379;443) | 62 | 5.11 | 221 (198;256) | 34 | 4.71 | 466 (431;505) | 71 | 4.97 |
Multivariate log-normal | 351 (316;388) | 54 | 5.02 | 338 (310;380) | 52 | 5.01 | 344 (305;377) | 53 | 4.71 | 344 (309;366) | 53 | 4.92 |
Multivariate normal | 376 (345;423) | 57 | 5.04 | 355 (318;395) | 54 | 5.21 | 366 (326;404) | 56 | 4.69 | 361 (331;397) | 55 | 4.81 |