Table 8 PCA on simulated data (ANT=655, nt = 1,500, PCs = 350): ENT estimates with 95% confidence intervals in brackets, and type I error estimation from the permutation procedure for various simulated outcome measures: continuous, discrete-binary, discrete-count, time-to-event survival
From: Multiple-testing correction in metabolome-wide association studies
Outcome type | Continuous | Binary | Count | Survival | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
PCA simulated data | ENT | R (%) | Type I error (%) | ENT | R (%) | Type I error (%) | ENT | R (%) | Type I error (%) | ENT | R (%) | Type I error (%) |
Identity | 292 (271;314) | 45 | 5.10 | 333 (307;360) | 51 | 4.93 | 500 (469;542) | 76 | 5.05 | 394 (371;427) | 60 | 4.95 |
Multivariate log-normal | 391 (365;417) | 60 | 4.99 | 377 (347;401) | 58 | 5.09 | 389 (360;414) | 59 | 4.98 | 379 (356;410) | 58 | 4.93 |
Multivariate normal | 368 (340;401) | 56 | 4.98 | 356 (332;384) | 54 | 5.01 | 370 (345;398) | 56 | 5.11 | 343 (320;368) | 52 | 5.19 |