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Table 8 PCA on simulated data (ANT=655, nt = 1,500, PCs = 350): ENT estimates with 95% confidence intervals in brackets, and type I error estimation from the permutation procedure for various simulated outcome measures: continuous, discrete-binary, discrete-count, time-to-event survival

From: Multiple-testing correction in metabolome-wide association studies

Outcome type Continuous Binary Count Survival
PCA simulated data ENT R (%) Type I error (%) ENT R (%) Type I error (%) ENT R (%) Type I error (%) ENT R (%) Type I error (%)
Identity 292 (271;314) 45 5.10 333 (307;360) 51 4.93 500 (469;542) 76 5.05 394 (371;427) 60 4.95
Multivariate log-normal 391 (365;417) 60 4.99 377 (347;401) 58 5.09 389 (360;414) 59 4.98 379 (356;410) 58 4.93
Multivariate normal 368 (340;401) 56 4.98 356 (332;384) 54 5.01 370 (345;398) 56 5.11 343 (320;368) 52 5.19
  1. \(K=5000\) permutations