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Fig. 5 | BMC Bioinformatics

Fig. 5

From: Density Peak clustering of protein sequences associated to a Pfam clan reveals clear similarities and interesting differences with respect to manual family annotation

Fig. 5

Example (protein R5WQE2) of nesting of an MC-A18_PUA region into a family of the “DUF362-like superfamily”—CL0471 clan. Solid-colored rectangles mark Pfam family annotations. The light red rectangle shows the actual region of R5WQE2 that aligns to the DUF362 profile-HMM. Note that in this specific case, even in the Pfam annotation nesting of Fer4_21 into DUF362 is not accounted for, resulting in two overlapping Pfam annotations. The yellow box marks a hit obtained using the profile-HMM derived from MC-A18_PUA

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BMC Bioinformatics

ISSN: 1471-2105

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