Fig. 4

Patient peripheral blood derived serial biomarker data. A data sample of 8 cytokines and 8 cells for one healthy volunteer (#10) and one cancer patient (#12A) across a study time period demonstrates the highly dynamic and fluctuating nature of the immune system. Values are the measured biomarker concentrations. Biomarker values are connected via linear interpolation, which approximates the oscillatory behaviors of the biomarkers over time, thus providing the computational analysis with a first order approximant model for all test period response data