Fig. 5

Quad Occurrence Count activity patterns. Observed Occurrence Counts for the bi-linear Quads across all participants present in similar cumulative pattern as shown. If a Doublet or Triplet has an Occurrence Count, first the Quad with the same cell in the Source, Target, and LSV must be active. Second, a Dominator Quad (same cytokine in the Target and LSV) Occurrence Count is observed. Finally, if both types of bi-linear Quads are active then Supporter Quads (different cytokine in the Target and LSV) Occurrence Counts are observed. Therefore, the higher the Doublet Occurrence Count the more activity is found in the Dominator and Supporter Quads