Skip to main content

Table 1 CICD data analysis for cancer patient 12A and healthy volunteer 10

From: Cancer immune control dynamics: a clinical data driven model of systemic immunity in patients with metastatic melanoma

BI-linear, modulated relationships Cancer patient 12A Healthy volunteer 10
Quad: Modulator, Source, Target, LSV
Triplet: Modulator, Source, Target  
Doublet: Modulator, Source  
Modulator Source Target LSV OCC. Count Sum OCC. count Sum
IP-10 CD3+ CD3+ CD3+ 100.00   100.00  
IP-10 CD3+ CD3+    Triplet: 100   Triplet: 100
IP-10a CD3+a IL-8a IL-8a 93.75   89.58  
IP-10 CD3+ IL-8 EOTAXIN 35.42   2.08  
IP-10 CD3+ IL-8 IP-10 29.17   2.08  
IP-10 CD3+ IL-8 MCP-1 29.17   6.25  
IP-10 CD3+ IL-8 VEGF 25.00   6.25  
IP-10 CD3+ IL-8 TGFA 20.83   16.67  
IP-10 CD3+ IL-8 IL-1A 20.83   8.33  
IP-10 CD3+ IL-8 EGF 18.75   4.17  
IP-10 CD3+ IL-8 IL-12P40 14.58   2.08  
IP-10 CD3+ IL-8 FGF-2 14.58   2.08  
IP-10 CD3+ IL-8 FRACTALKINE 14.58   4.17  
IP-10 CD3+ IL-8 G-CSF 12.50   0.00  
IP-10 CD3+ IL-8 IL-12P70 12.50   0.00  
IP-10 CD3+ IL-8 IL-1RA 12.50   4.17  
IP-10 CD3+ IL-8 IL-3 12.50   2.08  
IP-10 CD3+ IL-8 MCP-3 12.50   2.08  
IP-10 CD3+ IL-8 TNFB 12.50   2.08  
IP-10 CD3+ IL-8 IFN-G 10.42   0.00  
IP-10 CD3+ IL-8 IL-2 10.42   0.00  
IP-10 CD3+ IL-8 MIP-1A 10.42   0.00  
IP-10 CD3+ IL-8 GM-CSF 8.33   0.00  
IP-10 CD3+ IL-8 IFN-2A 8.33   2.08  
IP-10 CD3+ IL-8 IL-10 6.25   0.00  
IP-10 CD3+ IL-8 IL-13 6.25   4.17  
IP-10 CD3+ IL-8 IL-17A 6.25   0.00  
IP-10 CD3+ IL-8 IL-1B 6.25   4.17  
IP-10 CD3+ IL-8 IL-4 6.25   4.17  
IP-10 CD3+ IL-8 IL-9 6.25   4.17  
IP-10 CD3+ IL-8 MIP-1B 6.25   0.00  
IP-10 CD3+ IL-8 TNFA 6.25   2.08  
IP-10 CD3+ IL-8 FLT-3L 4.17   0.00  
IP-10 CD3+ IL-8 IL-7 4.17   2.08  
IP-10 CD3+ IL-8 IL-15 2.08   2.08  
IP-10 CD3+ IL-8 IL-6 2.08   4.17  
IP-10 CD3+ IL-8 IL-5 0.00   0.00  
IP-10 CD3+ IL-8   502.08 Triplet: 502.08 183.33 Triplet: 183.33
IP-10 CD3+     Doublet: 11,839.58b   Doublet: 5210.42b
Linear, non-modulated relationships Cancer patient 12A Healthy volunteer 10
Quad: Modulator, Source, Target, LSV
Triplet: Modulator, Source, Target  
Doublet: Modulator, Source   
Modulator Source Target LSV OCC. Count Sum OCC. Count Sum
n.a IL-8 CD3/CD69+ CD3/CD69+ 18.75 Triplet: 18.75 0.00 Triplet: 0
n.a IL-8 CD11c/CD86+ CD11c/CD86+ 10.42 Triplet: 10.42 0.00 Triplet: 0
n.a IL-8 CD11c/HLA-DR+ CD11c/HLA-DR+ 10.42 Triplet: 10.42 0.00 Triplet: 0
n.a IL-8 CD11c+ CD11c+ 8.33 Triplet: 8.33 0.00 Triplet: 0
n.a IL-8 CD4/CD294+ CD4/CD294+ 6.25 Triplet: 6.25 0.00 Triplet: 0
n.a IL-8 CD4/TIM3+ CD4/TIM3+ 6.25 Triplet: 6.25 0.00 Triplet: 0
n.a IL-8 CD56+ CD56+ 2.08 Triplet: 2.08 0.00 Triplet: 0
n.a IL-8    83.33 Doublet: 83.33 0.00 Doublet: 0
  1. 43 of the 10,869 active Quad’s for the cancer patient and 25 of the 10,757 active Quad’s for the healthy volunteer are presented. Every row represents one unique active Quad containing the four components (LSV, Target, Source, and Modulator) and a value for its Occurrence Count. Examples of both bi-linear, modulated relationships (top section) and linear non-modulated relationships (bottom) are shown. The Triplets have the same Target, Source, and Modulator and its value is the sum of all its LSVs Occurrence Counts. The Doublets have the same Source and Modulator, combining all Target and LSV biomarkers. The value is the sum of all Occurrence Counts that have this common Doublet within its Quad.
  2. aDominator LSV, Target and LSV are the same cytokine in Quad
  3. bActual Doublet Value is higher due to additional Quads not shown