TY - JOUR AU - Deng, Zachary AU - Delwart, Eric PY - 2021 DA - 2021/03/12 TI - ContigExtender: a new approach to improving de novo sequence assembly for viral metagenomics data JO - BMC Bioinformatics SP - 119 VL - 22 IS - 1 AB - Metagenomics is the study of microbial genomes for pathogen detection and discovery in human clinical, animal, and environmental samples via Next-Generation Sequencing (NGS). Metagenome de novo sequence assembly is a crucial analytical step in which longer contigs, ideally whole chromosomes/genomes, are formed from shorter NGS reads. However, the contigs generated from the de novo assembly are often very fragmented and rarely longer than a few kilo base pairs (kb). Therefore, a time-consuming extension process is routinely performed on the de novo assembled contigs. SN - 1471-2105 UR - https://doi.org/10.1186/s12859-021-04038-2 DO - 10.1186/s12859-021-04038-2 ID - Deng2021 ER -