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Fig. 7 | BMC Bioinformatics

Fig. 7

From: A machine learning-based gene signature of response to the novel alkylating agent LP-184 distinguishes its potential tumor indications

Fig. 7

Comparison of LP184 drug sensitivity profile with other drugs. a The frequency of different sensitivity levels is shown for each tissue for different drug groups. The IC50 is shown as a z-score, with the higher score indicating greater sensitivity of the corresponding cell lines or tissues. The global mean IC50 refers to the average z-score of each of the > 20,000 compounds in the NCI-60 dataset. b Pairwise comparisons of drug sensitivity in individual cell lines. For distinguishing points of interest, the point size is proportional to LP184 drug sensitivity. LP-184 shows higher z-scores for ovarian cancer, compared to the global average, and, in some lines, to individual drugs used clinically in ovarian cancer. c Table of IC50 z-score values for LP-184, paclitaxel, and carboplatin drugs, and the average of > 20,000 compounds, in 7 ovarian cancer lines from the NCI-60 panel

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BMC Bioinformatics

ISSN: 1471-2105

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