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Table 5 The top 10 interactions based on the expected relative interaction contribution (ERIC) estimated on the evaluation data (Phase 3), with the aim of explaining the best predictive models from Phase 2

From: A new method for exploring gene–gene and gene–environment interactions in GWAS with tree ensemble methods and SHAP values

Feature 1

Feature 2

ERIC

rs171329

rs180743

0.001

Sex

rs17817449

0.001

Saturated fat intake

rs17817449

0.00094

rs757318

rs12123815

0.0008

rs4697952

rs1488830

0.00074

rs60822591

rs17854357

0.00066

rs4711329

rs11676272

0.00066

rs1518278

rs1488830

0.0006

Sex

rs12123815

0.00056

rs7132908

rs9949796

0.00054