Table 2 Reactome pathway enrichment analysis for Interferon-α and -γ treatments
Interferon-α enrichment analysis | |||||
|---|---|---|---|---|---|
DeltaNeTS+ | GO terms | Log2FC | Reactome pathways | DeMAND | GO terms |
Type I interferon signaling pathway | Interferon alpha/beta signaling | Defense response to virus | |||
Negative regulation of viral genome replication | Interferon Signaling_Homo sapiens | Type I interferon signaling pathway | |||
Negative regulation of viral life cycle | Cytokine Signaling in Immune system | Cellular response to type I interferon | |||
Cellular response to type I interferon | Immune System_Homo sapiens | Interferon-gamma-mediated signaling pathway | |||
Regulation of viral genome replication | Antiviral mechanism by IFN-stimulated genes | Response to type I interferon | |||
Reactome pathways | ISG15 antiviral mechanism | Reactome pathways | |||
Interferon signaling | Interferon gamma signaling | Interferon alpha/beta signaling | |||
Interferon alpha/beta signaling | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | Interferon gamma signaling | |||
| Â | TRAF3-dependent IRF activation pathway | Interferon signaling | |||
| Â | Regulation of IFNA signaling | Â | |||
| Â | TRAF6 mediated IRF7 activation | Â | |||
| Â | Negative regulators of RIG-I/MDA5 signaling | Â | |||
Interferon-γ enrichment analysis | |||||
DeltaNeTS+ | GO terms | Log2FC | GO terms | DeMAND | No enriched term |
Antigen processing and presentation of exogenous peptide antigen via MHC class II | Interferon-gamma-mediated signaling pathway | Â | |||
Cellular response to interferon-gamma | Â | ||||
Antigen processing and presentation of exogenous peptide antigen | Cytokine-mediated signaling pathway | Â | |||
Reactome pathways | Â | ||||
Antigen processing and presentation of peptide antigen via MHC class II | Interferon signaling | Â | |||
Interferon gamma signaling | Â | ||||
Cellular response to interferon-gamma | Cytokine signaling in immune system | Â | |||
Interferon-gamma-mediated signaling pathway | Immune system | Â | |||
Reactome pathways | Interferon alpha/beta signaling | Â | |||
Interferon signaling | Translocation of ZAP-70 to immunological synapse | Â | |||
Interferon gamma signaling | Phosphorylation of CD3 and TCR zeta chains | Â | |||
MHC class II antigen presentation | PD-1 signaling | Â | |||
Cytokine signaling in immune system | MHC class II antigen presentation | Â | |||
| Â | Generation of second messenger molecules | Â | |||