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Table 3 WGCNA modules of DeltaNeTS+ perturbation scores

From: DeltaNeTS+: elucidating the mechanism of drugs and diseases using gene expression and transcriptional regulatory networks

Module

Sizea

Summary of enriched pathwaysc

DBd

M1

2863

DNA replication, cell cycle

GO & RP

M2

2803

Influenza Viral RNA Transcription and Replication, viral mRNA Translation

GO & RP

M3

2645

Defense response to virus, immune response, interferon signaling

GO & RP

M4

1427

Viral entry (GPCR binding, amine transport)

GO & RP

M5

888

Crosslinking of collagen fibrils

RP

M6

762

Apoptosis (TNFR2 non-canonical NF-kB pathway)

RP

M7

397

N/A

–

  1. RP reactome pathway database, GO gene ontology
  2. aThe number of genes clustered in each module
  3. bSummary of enriched pathways (q-value < 0.10) in each module
  4. cPathway databases used for enrichment analysis