Fig. 4

E. coli network diagram illustrating the logarithm of the deviation index (DI) of enzymatic reactions when scaling up from D1 to D2. Network of core reactions (edges) and metabolites (nodes) for D1 and D2 models. The DI is an indicator of difference in the control over a reaction with respect to all the enzymatic reactions of the network due to the network expansion (Methods). Reactions added by the redGEM expansion from D1 to D2 (red), and ones in common between D1 and D2 for low (0–25 percentile) DI (light gray), medium (25–75 percentile) DI (dark gray) and high (75–100 percentile) DI (black) are shown. The blue metabolites are common between D1 and D2, and red ones indicate metabolites resulting from the D2 expansion. Diagram does not include all the reactions of the systems. yEd Version 3.20.1 was used to generate the network diagram