Fig. 5

E. coli network diagram illustrating the logarithm of the deviation index (DI) of enzymatic reactions when scaling up from D2 to D3. Network of core reactions (edges) and metabolites (nodes) for D2 and D3 models. The DI is an indicator of difference in the control over a reaction with respect to all the enzymatic reactions of the network due to the network expansion (Methods). Reactions added by the redGEM expansion from D2 to D3 (green), and ones in common between D2 and D3 for low (0–25 percentile) DI (light gray), medium (25–75 percentile) DI (dark gray) and high (75–100 percentile) DI (black) are shown. The blue, red and green nodes correspond to metabolites common between D1 and D2, ones added by the D2 expansion and ones added by the D3 expansion, respectively. Diagram does not include all the reactions of the systems. yEd Version 3.20.1 was used to generate the network diagram