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Fig. 4 | BMC Bioinformatics

Fig. 4

From: Large-scale labeling and assessment of sex bias in publicly available expression data

Fig. 4

Sex breakdown by drug ATC class in human and mouse data. The breakdown shows enrichment of female only studies in human cancer drugs and male only studies in mouse drugs. Count breakdown of female only, male only, and mixed sex studies by class in humans (a) and mice (b) (* indicates p < 0.05 after Bonferroni correction). The fraction of studies for each individual drug is also shown in (c), where the x axis is the fraction of female only studies and the y axis is the fraction of male only studies. Each point is a drug, the size of the point indicates the number of studies that include that drug, and the color of the point is ATC class. Drug name labels are included for drugs with at least three studies and a strongly sex-biased ratio (\(> \,{\raise0.7ex\hbox{$2$} \!\mathord{\left/ {\vphantom {2 3}}\right.\kern-\nulldelimiterspace} \!\lower0.7ex\hbox{$3$}}\) of studies only one sex, \(< \,{\raise0.7ex\hbox{$1$} \!\mathord{\left/ {\vphantom {1 3}}\right.\kern-\nulldelimiterspace} \!\lower0.7ex\hbox{$3$}}\) the other); other labels are omitted for ease of visualization. For a full list of drugs see Additional file 2: Table S8

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