Fig. 3

SVs associated with disruption of TADs and translocated enhancers in cancer cell lines. a As compared to all SVs, fractions of SVs involving topologically associated domain (TAD) disruption and altered gene expression (defined as FDR < 10% for the gene using 1 Mb region window, with corrections for tumor type and CNA, and expression > 0.4SD or ≤ 4SD from the median for the case harboring the breakpoint). Results based on analysis of 327 cancer cell lines with WGS data [10]. p values by chi-squared test. b Percentages of SV breakpoint associations involving the translocation of an enhancer within 0.5 Mb of the SV breakpoint in proximity to the gene (and closer than any enhancer within 1 Mb of the unaltered gene), as tabulated for the entire set of SV breakpoint associations with breakpoint mate on the distal side from the gene, as well as for the subsets of SV breakpoint associations involving altered gene expression (defined as for part a). P values by chi-squared test. c By gene and by cancer type, the number of SV breakpoint associations involving the translocation of an enhancer, involving at least two cell lines per gene. Results involve 60 genes and 159 cell lines