Table 1 Hub genes of modules
From: Establishing a consensus for the hallmarks of cancer based on gene ontology and pathway annotations
Gene id | Gene name | Function | modules |
|---|---|---|---|
ENSG00000013725 | CD6 | Mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 | GO3_2, GO1_2 |
ENSG00000116824 | CD2 | Mediate adhesion between T-cells and other cell types | GO3_2, GO2_3, GO1_2 |
ENSG00000167286 | CD3D | Part of the TCR-CD3 complex,plays an essential role in adaptive immune response | GO3_2, GO1_2 |
ENSG00000198851 | CD3E | Part of the TCR-CD3 complex,plays an essential role in adaptive immune response | GO3_2, GO1_2 |
ENSG00000117091 | CD48 | Facilitate interaction between activated lymphocytes and involved in regulating T-cell activation | GO3_2, GO2_3, GO1_2 |
ENSG00000185811 | IKZF1 | Plays a role in the development of lymphocytes, B- and T-cells | GO2_3 |
ENSG00000162739 | SLAMF6 | Associated with innate immune system and class I MHC mediated antigen processing and presentation | GO2_3 |
ENSG00000183918 | SH2D1A | Plays a major role in the bidirectional stimulation of T and B cells | GO1_2 |