NoRCE: non-coding RNA sets cis enrichment tool

BMC Bioinformatics

Table 3 Brain disorder related biological process GO term enrichment results that show the TAD analysis enhancement

ID	Term	p-value	References
GO:0035023	Regulation of Rho protein signal transduction	0.0187	[66, 67]
GO:0035019	Somatic stem cell population maintenance	0.0205	[66]
GO:0006816	Calcium ion transport	0.0360	[66]
GO:0014068	Positive regulation of phosphatidylinositol 3-kinase signaling	0.0219	[66, 69, 92]
GO:0006511	Ubiquitin-dependent protein catabolic process	0.0277	[66, 93]
GO:0007417	Central nervous system development	0.0255	[94, 95]

The listed enriched GO terms are detected by enrichment analysis based on neighboring genes and TAD filtering but are undetected by enrichment analysis solely based on neighboring genes. The TAD information is obtained from adult dorsolateral prefrontal cortex data [52] study. For a given enriched term, we provide the p-value and a list of literature evidence that shows the link between brain disorders and the enriched term

ISSN: 1471-2105