Fig. 6

Compartmental pharmacokinetic-pharmacodynamic model of tumour growth after anticancer therapy. We have reproduced the simplified version of the PK-PD model of tumour growth, where the PK part is reduced to a single input and simulated the effect of drug potency (\(k_2\)) on tumour growth curves. The system of four ODEs describing the dynamics of the system visualised on a scheme above is integrated over a period of 18 days. We systematically changed the value of \(k_2\), assuming a single drug administration on Day 9. We have obtained the same results as in Fig. 4 in the original paper [40]. To reproduce these results run the tumour-growth-2004.ipynb Jupyter Notebook from the Additional file 6: Jupyter Notebook tumour-growth-2004.ipynb