Fig. 4
From: Correlation AnalyzeR: functional predictions from gene co-expression correlations
Analysis of BRCA1-NRF2 pathway interplay in bone cancer using Gene versus Gene List mode. a, b Results of comparing BRCA1 and NRF2 gene targets (“NFE2L2.V2” MSigDB gene set). a Interactive histogram showing the location of the NRF2-pathway genes (blue bars overlaid on histogram on left) within the correlation value distribution of BRCA1 with linked data table (right panel). P value determined from Pearson correlation. “Anti-correlation” and “Co-correlation” annotations not generated by Correlation AnalyzeR. b Density plot generated by permutation testing. The summit represents the empirically determined significance of BRCA1′s correlation with the NRF2 pathway (labeled “secondary genes” in plot) (see methods)