Table 1 Negative and positive mutations in RpoB of M. tuberculosis (MTB)
Type | Amino acid change |
|---|---|
Positive (123) | L42F L47R E82G I90L V170F V170G Q172H Q172K Q172L Q172P Q172R D265G P280S V359A T361I L378R T399A T400I F424L G426D T427P S428R L430P L430Q L430R S431A S431F S431P S431R S431T S431Y Q432K Q432L Q432P Q432R M434I D435A D435F D435G D435N D435V D435Y N437D S441F S441L S441Q S441Y G442V T444R H445C H445D H445F H445G H445L H445N H445P H445Q H445R H445Y R448C R448H R448L R448S S450F S450L S450P S450Q S450W S450Y A451E A451V L452H L452P L452R G453A G453C G453D G453S G453V G456S T482P P483L P483R I488V G489C I491F I491L I491M I491N I491S I491T I491V S493F S493Y V496L V496M F503S D545E D545N P551S D571A D574E R607H N658D R662H A670D H674R H674Y T676P C681W M707T H723D H723Y L731P L735Q H745Y E761D R827C H835P H835R I925V E978D G981D |
Negative (63) | N24D G28R P30S D53N E66K A69P V77M L80V P89L V109I D109E V113I M121I E132D M153T V179A S195R P233Q D270E L314V L316V A334D H343Q T350I P358L D362H G374S S388L M390T M440V L443F P454L N493S R511L D515Y T526S A544V D545A E563D A590G D634G E639G E639Q R661Q H674Q P682T V695L I789V E795V E825G P834L D851G A857T G890D L893R K944E A998V D1012G V1117L S1124A L1128Q V1129A A1143T |