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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Systematic interrogation of mutation groupings reveals divergent downstream expression programs within key cancer genes

Fig. 2

Subgrouping performance is consistent across breast cancer cohorts. Cancer gene subgrouping enumeration and classification was repeated using the luminal A sub-cohort of TCGA-BRCA. The colors for genes’ plotted points and pie charts correspond to those in Fig. 1. a Prediction AUCs for gene-wide classification tasks and subgrouping tasks enumerated in both METABRIC-(LumA) (x-axis) and TCGA-BRCA(LumA) (y-axis). Larger point size indicates a higher joint proportion of mutated samples (calculated as the geometric mean of the two cohort proportions). b Comparison of relative subgrouping performance (AUC) between cancer genes profiled in TCGA-BRCA(LumA) (filled-in pie charts) versus those profiled in METABRIC(LumA) (hollow pie charts)

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BMC Bioinformatics

ISSN: 1471-2105

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