Fig. 1

Method overview. a Network neighborhood around viral protein in the PPI, including direct interactors as well as specific second neighbors. b Gene neighborhood around endpoint function that contains genes that are prioritized or predicted to be important causal effectors based on an ML model leveraging the CGE and CGF. c Intersection of viral neighborhoods with function neighborhoods. d Addition of network context in the KG using a heuristic involving shortest paths. Genes in the resulting network are viewed as potential drug targets interfering with the functional effect of viral proteins, and are annotated with existing drugs