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Table 3 Functional analysis of selected gene module

From: Simultaneous learning of individual microRNA-gene interactions and regulatory comodules

Index

Top Networks

Cancer

q-value

1

Behavior, Endocrine System Development and Function, Cancer (35)

77/88

1.77-2

7

Connective Tissue Disorders, Developmental Disorder, Gastrointestinal Disease (46); Organismal Injury and Abnormalities, Renal Damage, Renal and Urological Disease (40)

107/122

2.85-2

9

Cancer, Organismal Injury and Abnormalities, Reproductive System Disease (57)

66/81

4.5-2

36

Cellular Movement, Immune Cell Trafficking, Connective Tissue Development and Function (43); Cellular Development, Cellular Growth and Proliferation, Connective Tissue Development and Function (43)

110/138

1.53-2

61

Cell Death and Survival, Cellular Compromise, Cell-To-Cell Signaling and Interaction (50); Endocrine System Disorders, Gastrointestinal Disease, Immunological Disease (37); Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking (35); Inflammatory Response, Cell Death and Survival, Cellular Compromise (35)

183/195

1.36-7

63

Lipid Metabolism, Small Molecule Biochemistry, Connective Tissue Development and Function (38); Cardiovascular Disease, Cell Death and Survival, Connective Tissue Disorders (38)

137/157

6.42-3

67

Cell Morphology, Cellular Function and Maintenance, Molecular Transport (46); Cancer, Connective Tissue Disorders, Organismal Injury and Abnormalities (41)

98/123

1.29-3

90

Connective Tissue Development and Function, Skeletal and Muscular System Development and Function, Tissue Development (36)

68/76

9.59-2

93

Hematological System Development and Function, Lymphoid Tissue Structure and Development, Tissue Morphology (40); Cancer, Dermatological Diseases and Conditions, Hematological Disease (38)

78/86

4.77-4

109

Cancer, Connective Tissue Disorders, Organismal Injury and Abnormalities (45)

84/102

1.52-3

110

Behavior, Cell-To-Cell Signaling and Interaction, Cellular Growth and Proliferation (40); Carbohydrate Metabolism, Cellular Function and Maintenance, Small Molecule Biochemistry (40)

85/101

1.47-2

  1. Index, comodule index; Top Networks, top biological networks as identified by IPA software. Parenthesized value is the negative log of Fisher’s exact test p-value; Cancer, number of cancer-related genes within this comodule according to IPA software compared to total number of genes; q-value, multiple-test-corrected p-value of enrichment in cancer genes as reported by software