A detailed map of coupled circadian clock and cell cycle with qualitative dynamics validation

BMC Bioinformatics

Table 1 Summary of experimentally validated molecular interactions between the circadian clock and the mammalian cell cycle molecular networks

Clock		Cell cycle	Phase	Mechanism	Output	Ref.
ARNTL:CLOCK	\(\rightarrow\)	Wee1	G2/M	Transcriptional	Activation	[2]
NR1D1	\(\rightarrow\)	Cdkn1a	G1	Transcriptional	Repression	[4]
RORG	\(\rightarrow\)	Cdkn1a	G1	Transcriptional	Activation	[4]
NONO	\(\rightarrow\)	Cdkn2a	G1	Transcriptional	Activation	[34]
NR1D1	\(\leftarrow\)	CDK1	G2/M	Phosphorylation	Degradation	[35]
PER1	\(\rightarrow\)	CHEK2:ATM	S	Complex formation	DNA damage induced apoptosis	[3]
CRY2:TIM	\(\rightarrow\)	CHEK2:ATM	S	Complex formation	Defective intra-S checkpoint	[36]
PER2	\(\leftarrow\)	TP53	S	Nuclear translocation	Stabilisation	[37]

Arrows represent the direction of the influences (\(\rightarrow\): from the circadian clock to cell cycle; \(\leftarrow\): from the cell cycle to the circadian clock). All reported interactions have evidence in the literature

ISSN: 1471-2105