From: A detailed map of coupled circadian clock and cell cycle with qualitative dynamics validation
Clock | Cell cycle | Phase | Mechanism | Output | Ref. | |
---|---|---|---|---|---|---|
ARNTL:CLOCK | \(\rightarrow\) | Wee1 | G2/M | Transcriptional | Activation | [2] |
NR1D1 | \(\rightarrow\) | Cdkn1a | G1 | Transcriptional | Repression | [4] |
RORG | \(\rightarrow\) | Cdkn1a | G1 | Transcriptional | Activation | [4] |
NONO | \(\rightarrow\) | Cdkn2a | G1 | Transcriptional | Activation | [34] |
NR1D1 | \(\leftarrow\) | CDK1 | G2/M | Phosphorylation | Degradation | [35] |
PER1 | \(\rightarrow\) | CHEK2:ATM | S | Complex formation | DNA damage induced apoptosis | [3] |
CRY2:TIM | \(\rightarrow\) | CHEK2:ATM | S | Complex formation | Defective intra-S checkpoint | [36] |
PER2 | \(\leftarrow\) | TP53 | S | Nuclear translocation | Stabilisation | [37] |